CovidV1, an2020, Analysis, bibRecord, 000488

Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China.

Identifieur interne : 000488 ( an2020/Analysis ); précédent : 000487; suivant : 000489

Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China.

Source :

Science China. Life sciences [ 1869-1889 ] ; 2020.

RBID : pubmed:32146694

Abstract

Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease (COVID-19) and the evidence of person-to-person transmission. Limited data are available for asymptomatic infections. This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers. Epidemiological investigations were conducted among all close contacts of COVID-19 patients (or suspected patients) in Nanjing, Jiangsu Province, China, from Jan 28 to Feb 9, 2020, both in clinic and in community. Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples. Their clinical records, laboratory assessments, and chest CT scans were reviewed. As a result, none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening. Five cases (20.8%) developed symptoms (fever, cough, fatigue, etc.) during hospitalization. Twelve (50.0%) cases showed typical CT images of ground-glass chest and 5 (20.8%) presented stripe shadowing in the lungs. The remaining 7 (29.2%) cases showed normal CT image and had no symptoms during hospitalization. These 7 cases were younger (median age: 14.0 years; P=0.012) than the rest. None of the 24 cases developed severe COVID-19 pneumonia or died. The median communicable period, defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests, was 9.5 days (up to 21 days among the 24 asymptomatic cases). Through epidemiological investigation, we observed a typical asymptomatic transmission to the cohabiting family members, which even caused severe COVID-19 pneumonia. Overall, the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization. However, the communicable period could be up to three weeks and the communicated patients could develop severe illness. These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests. Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged.

DOI: 10.1007/s11427-020-1661-4
PubMed: 32146694

Affiliations:

République populaire de Chine

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pubmed:32146694

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<author><name sortKey="Wang, Jianming" sort="Wang, Jianming" uniqKey="Wang J" first="Jianming" last="Wang">Jianming Wang</name>
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<author><name sortKey="Chen, Yaling" sort="Chen, Yaling" uniqKey="Chen Y" first="Yaling" last="Chen">Yaling Chen</name>
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<author><name sortKey="Ma, Hongxia" sort="Ma, Hongxia" uniqKey="Ma H" first="Hongxia" last="Ma">Hongxia Ma</name>
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<author><name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name>
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<author><name sortKey="Lin, Yuan" sort="Lin, Yuan" uniqKey="Lin Y" first="Yuan" last="Lin">Yuan Lin</name>
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<author><name sortKey="Wang, Jianming" sort="Wang, Jianming" uniqKey="Wang J" first="Jianming" last="Wang">Jianming Wang</name>
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<author><name sortKey="Yi, Yongxiang" sort="Yi, Yongxiang" uniqKey="Yi Y" first="Yongxiang" last="Yi">Yongxiang Yi</name>
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<front><div type="abstract" xml:lang="en">Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease (COVID-19) and the evidence of person-to-person transmission. Limited data are available for asymptomatic infections. This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers. Epidemiological investigations were conducted among all close contacts of COVID-19 patients (or suspected patients) in Nanjing, Jiangsu Province, China, from Jan 28 to Feb 9, 2020, both in clinic and in community. Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples. Their clinical records, laboratory assessments, and chest CT scans were reviewed. As a result, none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening. Five cases (20.8%) developed symptoms (fever, cough, fatigue, etc.) during hospitalization. Twelve (50.0%) cases showed typical CT images of ground-glass chest and 5 (20.8%) presented stripe shadowing in the lungs. The remaining 7 (29.2%) cases showed normal CT image and had no symptoms during hospitalization. These 7 cases were younger (median age: 14.0 years; P=0.012) than the rest. None of the 24 cases developed severe COVID-19 pneumonia or died. The median communicable period, defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests, was 9.5 days (up to 21 days among the 24 asymptomatic cases). Through epidemiological investigation, we observed a typical asymptomatic transmission to the cohabiting family members, which even caused severe COVID-19 pneumonia. Overall, the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization. However, the communicable period could be up to three weeks and the communicated patients could develop severe illness. These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests. Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged.</div>
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<affiliations><list><country><li>République populaire de Chine</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Hu, Zhiliang" sort="Hu, Zhiliang" uniqKey="Hu Z" first="Zhiliang" last="Hu">Zhiliang Hu</name>
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<name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name>
<name sortKey="Chen, Yaling" sort="Chen, Yaling" uniqKey="Chen Y" first="Yaling" last="Chen">Yaling Chen</name>
<name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name>
<name sortKey="Jin, Guangfu" sort="Jin, Guangfu" uniqKey="Jin G" first="Guangfu" last="Jin">Guangfu Jin</name>
<name sortKey="Lin, Yuan" sort="Lin, Yuan" uniqKey="Lin Y" first="Yuan" last="Lin">Yuan Lin</name>
<name sortKey="Ma, Hongxia" sort="Ma, Hongxia" uniqKey="Ma H" first="Hongxia" last="Ma">Hongxia Ma</name>
<name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name>
<name sortKey="Song, Ci" sort="Song, Ci" uniqKey="Song C" first="Ci" last="Song">Ci Song</name>
<name sortKey="Wang, Jianming" sort="Wang, Jianming" uniqKey="Wang J" first="Jianming" last="Wang">Jianming Wang</name>
<name sortKey="Xu, Chuanjun" sort="Xu, Chuanjun" uniqKey="Xu C" first="Chuanjun" last="Xu">Chuanjun Xu</name>
<name sortKey="Xu, Xin" sort="Xu, Xin" uniqKey="Xu X" first="Xin" last="Xu">Xin Xu</name>
<name sortKey="Yi, Yongxiang" sort="Yi, Yongxiang" uniqKey="Yi Y" first="Yongxiang" last="Yi">Yongxiang Yi</name>
<name sortKey="Zheng, Yishan" sort="Zheng, Yishan" uniqKey="Zheng Y" first="Yishan" last="Zheng">Yishan Zheng</name>
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{{Explor lien
   |wiki=    Wicri/Sante
   |area=    CovidV1
   |flux=    an2020
   |étape=   Analysis
   |type=    RBID
   |clé=     pubmed:32146694
   |texte=   Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China.
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/an2020/Analysis/RBID.i   -Sk "pubmed:32146694" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidV1

This area was generated with Dilib version V0.6.33.
Data generation: Fri Mar 27 18:14:15 2020. Site generation: Sun Jan 31 15:15:08 2021

Serveur d'exploration Covid

Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China.

Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China.

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Abstract

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	Serveur d'exploration Covid
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.